Change in renal function post-nephrectomy for renal cell carcinoma in patients with and without hypertension and/or diabetes

Background: The standard of care for surgically resectable disease renal cell carcinoma (RCC) is a nephrectomy. Post nephrectomy, these patients are at risk the development new onset chronic kidney or progression pre-existing disease. We aimed to report changes in function who had nephrectomy RCC. Methods: This retrospective, descriptive, cross-sectional study identified 137 RCC from 1 January 2009 31 December 2017. pre-nephrectomy and post-nephrectomy estimated glomerular filtration rate (eGFR) histological subtype on histopathological analysis resected specimen were recorded National Health Laboratory Services online results platform. All analyses conducted using SPSS (Version 25) significance level was set p < 0.05. Results: After mean follow-up period 26.5 ± 22 months (median = 19 months), patients’ eGFR dropped by 4.82 8.67 ml/min/1.73 m2 (95% CI 3.23–6.41) post-nephrectomy. fall hypertension and/or diabetes (n 63) significantly larger compared neither comorbidities 54; .001; 7.30 8.40 5.19–9.42) 1.93 8.14 0.30–4.15) respectively. Conclusions: decline with mellitus more pronounced than comorbidities. In high-risk patients, measures must be taken prevent limit